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KMID : 0670719970020010025
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Journal of the Korean Society Hyperthermia Oncology
1997 Volume.2 No. 1 p.25 ~ p.28
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Mechanism of Cell Death by Heat- Brief Review -
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Masami Watanabe
Keiji Nakahata/Keiji Suzuki/Seiji Kodama/Tsutomu Sugahara
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Abstract
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It is expected that cancer organization is easy to be suppressed by a heat compared with a normal organization from clinical experience. Because there is not a target by heredity matter as for heat-treatment, there are a few hereditary side effects. There is the advantage that the effect that may be used together with radiation is provided. For reasons of the above, hyperthermia attracts attention as the most effective cancer treatment method. However, mechanism of cell death by heating isn't clear. Metabolism activity of cancer organization is high, and, therefore, generally, cancer organization is the acidity. Therefore, it regards many researchers as one cause that cancer organization is the acidity of cancer organization. In fact, heat-treatment in an acid condition lets a survival fraction of cell population fall remarkably. Recently, we investigated the heat-sensitivity of normal human cells and cells derived from human cancer cells. There was no difference between the heat sensitivity of exponentially growing normal cells and that of cancer cells at cloning density in situ. When confluent cultures were heated in situ, only normal human cells showed reduced heat sensitivity, which was 4-5 times less than that of exponentially growing cells. This shows that there is no difference in heat sensitivity between normal cells and cancer cells at single cell level, but only cancer cells may be lost the compartment of normal cell possessed mechanism to become heat resistance through cell contact, but cancer do not. Perhaps, membrane abnormality of a cancer cell includes the cause of hypersensitivity to heat.
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